A role for adenosine A(1) receptor blockade in the ability of caffeine to promote MDMA "Ecstasy"-induced striatal dopamine release. To know about the caffeine overdose symptoms, read the article below. Heffernan, T. P., Kawasumi, M., Blasina, A., Anderes, K., Conney, A. H., and Nghiem, P. ATR-Chk1 pathway inhibition promotes apoptosis after UV treatment in primary human keratinocytes: potential basis for the UV protective effects of caffeine. View abstract. J.Anal.Toxicol. Eur.J.Clin.Pharmacol. Welborn, L. G., de Soto, H., Hannallah, R. S., Fink, R., Ruttimann, U. E., and Boeckx, R. The use of caffeine in the control of post-anesthetic apnea in former premature infants. View abstract. View abstract. 2010;20 Suppl 1:S35-S49. 2006;16(1):69-77. Petrie HJ, Chown SE, Belfie LM, et al. J.Appl.Physiol 2004;96(1):50-58. Caffeine might block the affects of dipyridamole (Persantine). J Sleep Res 2008;17(3):309-321. View abstract. Campana C, Griffin PL, Simon EL. 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Some estrogen pills include conjugated equine estrogens (Premarin), ethinyl estradiol, estradiol, and others. Abernethy DR, Todd EL. Pharmacogenetics 1996;6(3):213-222. Quiz: What Do You Know About Vitamin B12 Deficiency? Jie KG, Bots ML, Vermeer C, et al. Indian J Med Res 2010;132:36-41. Fuglsang, G., Nielsen, K., Kjaer, Nielsen L., Sennels, F., Jakobsen, P., and Thelle, T. The effect of caffeine compared with theophylline in the treatment of idiopathic apnea in premature infants. 10-13-2010;58(19):10582-10589. Dikici S, Saritas A, Kilinc S, Guneysu S, Gunes H. Does an energy drink cause a transient ischemic attack? In terms of caffeine dosage, those four cups of coffee are about 400 milligrams of caffeine. View abstract. Does Caffeine interact with other medications? Orozco-Gregorio, H., Mota-Rojas, D., Bonilla-Jaime, H., Trujillo-Ortega, M. E., Becerril-Herrera, M., Hernandez-Gonzalez, R., and Villanueva-Garcia, D. 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Taking caffeine along with riluzole (Rilutek) might decrease how fast the body breaks down riluzole (Rilutek) and increase the effects and side effects of riluzole (Rilutek). View abstract. Zuchinali P, Riberio PA, Pimentel M, da Rosa PR, Zimerman LI, Rohde LE. Osswald, H. and Schnermann, J. Methylxanthines and the kidney. Behavioral and physiological effects of xanthines in nonhuman primates. Any more than that and the “heavy caffeine use can cause unpleasant side effects,” it says. 2001;(4):CD001072. N Engl J Med 1999;341:1688-9. Journal of Exercise Science & Fitness 2008;6(2):115-120. Waugh, E. J., Lam, M. A., Hawker, G. A., McGowan, J., Papaioannou, A., Cheung, A. M., Hodsman, A. 1989;18(1):94-97. Astrup, A., Toubro, S., Cannon, S., Hein, P., Breum, L., and Madsen, J. Caffeine: a double-blind, placebo-controlled study of its thermogenic, metabolic, and cardiovascular effects in healthy volunteers. View abstract. Caffeine ingestion before an oral glucose tolerance test impairs blood glucose management in men with type 2 diabetes. Potential toxicity of caffeine when used as a dietary supplement for weight loss. Eur.J Clin Pharmacol 1981;21(1):45-52. pii: E611. Eur.Neurol. Methylphenidate vs dextroamphetamine vs caffeine in minimal brain dysfunction: controlled comparison by placebo washout design with Bayes' analysis. Rudolph, T. and Knudsen, K. A case of fatal caffeine poisoning. Horner NK, Lampe JW. So, what causes it? Report of a human fatality due to caffeine. View abstract. 2002;18(1):18-25. View abstract. Psychopharmacology (Berl) 1997;129:1-14. Sports Med 2018;48(10):2425-41. doi: 10.1007/s40279-018-0967-4. PLoS One. Am.J.Cardiol. View abstract. Appl Physiol Nutr Metab 2009;34(4):754-762. Avisar R, Avisar E, Weinberger D. Effect of coffee consumption on intraocular pressure. Mental alertness. View abstract. View abstract. View abstract. 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